Glucotru Ingredients
Glucosamine is an amino-sugar compound and the most abundant monosaccharide in living organisms. It has been used extensively in the last two decades due to the fact that it is attributed to beneficial properties in joint pathologies.
What is glucosamine for?
In humans, glucosamine has
been shown to decrease the production of certain enzymes and inflammatory
markers in the synovial cells of patients with Osteoarthritis.
Glucosamine is an essential
part of the cartilage component and other joint elements. The endogenous or
proper production of glucosamine seems to be no less in patients with
Arthritis.
Nor has it been shown that
orally administered glucosamine markedly improves pain or inflammation. The
results of the studies have been very controversial.
What is chondroitin for?
Chondroitin is the largest
component of the extracellular matrix of many tissues: ligaments, joints,
tendons and bones. They have an anti-inflammatory effect in certain tissues and
decrease the production of specific enzymes and specific cytokines in the joints
that can intervene in the process of joint degeneration.
In such a way, that its use
has been proposed in cases of Osteoarthritis and joint pain.
What is glucosamine - chondroitin for?
Since glucosamine and
chondroitin are structural components of cartilage and tissues such as
ligaments and tendons, the combination has been used commercially as a more
effective alternative for osteoarthritis.
However, there are no studies
that reveal that its action is potentiated jointly as it happens with other
combinations of medicines available for other purposes.
Where is natural glucosamine?
Natural glucosamine is
naturally generated in the liquid matter found around the joints of the osseous
system of animals, including the bone marrow.
It is also abundant in the
shell of the shellfish from where the glucosamine sulfate is extracted.
From there it is obtained for
the preparation of dietary supplements and some fungi. It is also synthesized
in pharmaceutical laboratories.
In what presentations is glucosamine?
Glucosamine is often consumed
orally and comes in different forms, including:
·
Glucosamine
sulfate.
·
Glucosamine
hydrochloride.
·
N-acetyl-glucosamine.
Glucosamine can also be
combined with other components such as chondroitin sulfate,
methylsulfonylmethane (MSM) and shark cartilage.
What is chondroitin?
Chondroitin is a compound
similar to glucosamine and is also found naturally in joints. MSM is another
natural substance present in animals and plants that can also be synthesized.
As stated in the Clinical
Protocols of the University of Western States, scientific research is not
conclusive about the effectiveness of these combined supplements. Most recent
studies have focused on the role of glucosamine sulfate
The effectiveness of the
mixtures with MSM and chondroitin is demonstrated.
How does glucosamine work?
Glucosamine is essential for
the constitution of cartilage, resistant and elastic connective tissues that
are part of the skeleton and other parts of the body.
The firm and rubbery cartilage
tissues function as end connectors, in which the long bones join with the
joints.
The cartilages will be less
flexible over the years increasing the risk of breakage. There is evidence that
glucosamine could delay this cartilaginous deterioration.
Other proposed mechanisms of action
Researchers believe that the
sulfur contained in glucosamine is the agent that benefits the health of the
cartilage, joining them to build and repair them. Glucosamine also plays a role
in this incorporation of the non-metallic element into the connective
tissues.
The amount of glucosamine in
the cartilage will decrease with aging, a deficiency that could be linked to
the deterioration of the joints.
Why do people take glucosamine supplements?
The National Health Interview
Survey established in 2007 that 17.7% of adults in the United States, regularly
consume some kind of dietary supplement and of these, 19.9% lean towards
glucosamine, according to the Center National of Complementary and Alternative
Therapies.
According to this survey,
glucosamine is the second dietary supplement most used by Americans, second
only to those of the Omega 3 family (fish oil, DHA and Omega 3), with a
preference of 37.4% of adults they are supplemented
Benefits of glucosamine
Among the classic benefits of
glucosamine
·
Improvement of
pain in degenerative osteoarthritis and arthritis
·
Improvement of
joint stiffness.
·
Provides a
component that has been delayed joint wear process
·
It reduces the
symptoms of osteoporosis.
Although the use of
glucosamine is currently questioned, it has been proposed for many other
problems, with less scientific evidence.
Other unproven uses of glucosamine
The consultation also allowed
us to know why Americans consume the supplement, despite not being
scientifically proven its use for such effects. The following are the reasons:
·
Osteoarthritis
(OA).
·
For weight loss.
·
Treat glaucoma
·
For interstitial
cystitis, a chronic condition that causes pain or pressure in the bladder.
·
Treatment of pain
in the jaw.
·
Treat pain in the
knees and other joints.
·
To overcome back
pain.
·
Multiple sclerosis
Can glucosamine help with
osteoarthritis (OA)?
There are many investigations
with divergent results.
Based on scientific studies,
glucosamine could:
·
Reduce stiffness,
inflammation and pain associated with osteoarthritis of the joints.
·
Improve the
functionality of patients with osteoarthritis of the knee or hip.
·
Relieve symptoms
of OA up to 3 months after stopping treatment.
Many patients use glucosamine
supplements for osteoarthritis. Particularly
in the hip and knee, there is no evidence to prove its effectiveness
Controversial scientific studies
According to a meta-analysis,
which collects information on numerous important works in Osteoarthritis. The
evidence indicates that it may have benefits for joint pain. But there are no
conclusive results of the improvement in the cartilage of people with
arthritis.
A review was made by the
University of Tennessee on the use of glucosamine alone in patients with
osteoarthritis. It was concluded that glucosamine provides a very discreet
relief of symptoms in these cases.
Although it is not ruled out
that the combination or the single use of glucosamine could alleviate pain in
people with osteoporosis. However, the results seem to point out that it is not
very effective in reducing the loss of articular cartilage.
The National Health Interview
Survey also points out that although many people use glucosamine-containing
creams for arthritic pain, these products often include camphor among their
ingredients.
What is glucosamine and contraindications for?
Glucosamine has been raised
for joint wear problems, decrease joint pain and regenerate cartilage in some
types of arthritis.
In turn, it has been seen that
the consumption of glucosamine can be harmful in obese patients, with metabolic
syndrome and diabetics.
Scientific studies around the
world have not proven effective enough to recommend its use massively.
In such a way, we must weigh
the use of the drug with unproven benefits with contraindications and possible
adverse effects,
There is no guarantee on
whether it is glucosamine or any of these other components which provides
relief from the pain of arthritis. There is also no evidence that the
amino-sugar compound is absorbed by the skin.
Does glucosamine have other uses?
Glucosamine has other
benefits. At the experimental level, some effect of glucosamine was shown as a
treatment in patients with inflammatory bowel diseases.
Scientists have documented,
after the evidence of some experimental work done in mice with the
supplementation of N-acetyl glucosamine (GlcNAc) for multiple sclerosis, that
there is no statistical evidence of beneficial effects in humans on this
disease.
Glucosamine used with
Ibuprofen helps reduce pain in people with temporomandibular joint disorders,
according to another scientific study.
Despite not having conclusive
scientific basis, this supplement has been recommended in the treatment of
diseases and medical conditions. The following are conditions for which this
natural remedy is ineffective:
·
Allergies
·
Sports injuries.
·
Chronic lumbar
pain.
·
Venous
insufficiency that affects the circulation of blood through the legs.
The American Association of
Family Physicians suggests that asthmatics should use glucosamine with caution,
since it has been linked to the respiratory condition.
Benefits of glucosamine in the gym
It has been shown that sports
and high impact exercises can contribute to the appearance of Osteoarthritis,
particularly in knees. In turn, moderate or mild exercise in healthy
individuals does not seem to predispose to any degenerative disease.
In the case of athletes and
athletes with stronger and more durable training, it has been tried to seek
help in supplements that allow delaying or avoiding joint wear with greater
movement and impact.
So far it has not been shown
that glucosamine can have that benefit.
How is glucosamine used?
Glucosamine is an
over-the-counter product. It is found in glucosamine tablets with chondroitin
and with some vitamins such as D3. Your dosages will vary depending on the
reason for consumption, so it will be necessary to respect the doctor's
instructions.
The most common dose of
glucosamine is a 500 mg pill 3 times a day, both for osteoarthritis and for
temporomandibular joint disorder.
What are the side effects of glucosamine?
Although it is well tolerated
by the body, glucosamine may cause mild side effects. Among them stomach upset,
nausea, diarrhea, burning in the stomach and constipation. They are added:
·
Headache.
·
Skin reactions
·
Fatigue.
·
Drowsiness.
·
Irritations of the
skin
Taking the supplement with
meals may alleviate some of these unwanted responses.
Does glucosamine make you fat?
Glucosamine does not make you
fat or cause any significant change in body weight.
Glucosamine: contraindications for hypertensive
Glucosamine sulfate by itself
is not a problem for high blood pressure. The difficulty lies in the fact that
almost all oral glucosamine and glucosamine preparations with chondroitin have
a high salt content, even greater than 20% of the established daily salt dose.
For hypertensive people who
are difficult to manage or people who are very sensitive to the salt content in
food, they should be restricted.
You should check with your
doctor if it is safe to take glucosamine with Hypertension and look for
pharmacological presentations without salt content.
What contraindications does glucosamine have?
In the National Survey of
Health Interviews of the United States it was concluded that a correct use of
glucosamine is "probably safe". Glucosamine, therefore, has few
relative contraindications: Asthma, diabetes or glucose tolerance,
hyperinsulinism, allergies to the product.
The scientific and medical
community debates whether this supplement increases the blood glucose level in
diabetics. Evidence suggests that this probably does not occur in patients with
type 2 diabetes.
It is known that glucosamine
supplements made from seafood can produce hypersensitivity in susceptible
people. The most responsible will be to avoid this amino-sugar if you have or
have suffered an allergy to these marine animals.
Interactions of Glucosamine
The doctor will be informed of
over-the-counter and prescription medications, supplements, powdered proteins,
vitamins, medicinal herbs and other consumed products, if a glucosamine
supplement is to be ingested. The specialist will decide whether to modify the
dosage or suspend the intake of any of these products, to avoid an
interaction.
The interactions could
diminish or cancel the benefits expected from the use of one or several
supplements and even favor the manifestation of known or new side effects.
The patient will ask the
doctor how safe it will be to add glucosamine together with the use of the
following medications or products:
Most common interactions
·
Non-steroidal
anti-inflammatory drugs such as Ibuprofen (Motrin, Relafen, Advil) and Naproxen
(Anaprox, Aleve, Naprosyn).
·
Medications to
prevent the adherence of platelets to each other such as Prasugrel (Effient)
and Clopidogrel (Plavix).
·
Anticoagulants
such as Heparin, Warfarin (Jantoven, Coumadin), Rivaroxaban (Xarelto), Apixaban
(Eliquis), Fondaparinux (Arixtra), Enoxaparin (Lovenox) and Dabigatran
(Pradaxa).
·
Antidepressants
such as Venlafaxine (Effexor) and Citalopram (Celexa).
·
Drugs for
anticancer chemotherapy treatments such as Doxorubicin (Adriamycin) and
Etoposide (Etopophos).
·
Medications for
diabetes such as insulin, Rosiglitazone (Avandia) and Pioglitazone (Actos).
Glucose that is part of glucosamine may increase blood sugar.
Interactions with natural medicines
·
Herbal supplements
containing some species of the genus Scutellaria. The combination of
glucosamine with this herbal supplement could have liver consequences.
What can happen if I do not
use glucosamine according to the recommended dose?
If you interrupt the use of the supplement or do not
take it at all
Not only will arthritic,
osteoarthritic and other medical conditions not improve, they could also get
worse.
If you forget a dose
The patient will take the
missed dosage when remembering it, not if the next dose is within a few hours
of being administered as planned. You should not take two simultaneous doses if
you miss a dose.
If you take too much
Administering doses much
higher than what is prescribed for glucosamine could cause harmful effects to
health. The patient will immediately call the doctor, attend the poisoning
center or go to the emergency service if he consumes an overdose of the
amino-sugar.
It will also be necessary to
contact the doctor if the side effects do not disappear in a short time, if
more attempts are made or if others are not described in this article.
What other aspects of interest can you point to
regarding glucosamine?
Consumption during pregnancy and lactation
With limited evidence, it
seems that there are no serious effects in pregnancy, however, the patient in a
state or with plans to become pregnant or breastfeeding consult with the doctor
before consuming glucosamine.
Glucosamine and some drinks
Interactions between
glucosamine and alcohol are not ruled out, so consumption of the latter is not
recommended during the intake of the supplement.
The medicine is not sure if
grapefruit juice interferes with the breakdown process of glucosamine in the
liver. The most responsible thing is not to eat grapefruit or drink its juice
during the intake of the supplement.
Glucosamine and pets
Studies suggest that
glucosamine and chondroitin may alleviate pain in cats, dogs and horses,
especially by cartilage wear in the hip joint. The correct thing to do is to
contact the veterinarian before supplementing a glucosamine-based compound to
pets.
Storage
Glucosamine will be stored in
a clean, dry place, without heat, out of direct light and without moisture.
Additional precaution
The patient will not offer or
recommend the supplement to other people without medical supervision, or for
presenting symptoms similar to yours.
Glucosamine is relatively safe
as long as the guidelines recommended for adults without allergies and non-asthmatics
are respected.
If you liked this article,
share it with your friends on social networks, so that they also know what
glucosamine is, what its benefits are and how serious its side effects are.
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